A Molecular Signature Predictive of Indolent Prostate Cancer
نویسندگان
چکیده
منابع مشابه
A molecular signature predictive of indolent prostate cancer.
Many newly diagnosed prostate cancers present as low Gleason score tumors that require no treatment intervention. Distinguishing the many indolent tumors from the minority of lethal ones remains a major clinical challenge. We now show that low Gleason score prostate tumors can be distinguished as indolent and aggressive subgroups on the basis of their expression of genes associated with aging a...
متن کاملA four gene signature predictive of recurrent prostate cancer
Prostate cancer is the most common form of non-dermatological cancer among US men, with an increasing incidence due to the aging population. Patients diagnosed with clinically localized disease identified as intermediate or high-risk are often treated by radical prostatectomy. Approximately 33% of these patients will suffer recurrence after surgery. Identifying patients likely to experience rec...
متن کاملMolecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel
Docetaxel is a cornerstone treatment for metastatic, castration resistant prostate cancer (CRPC) which remains a leading cause of cancer-related deaths, worldwide. The clinical usage of docetaxel has resulted in modest gains in survival, primarily due to the development of resistance. There are currently no clinical biomarkers available that predict whether a CRPC patient will respond or acquir...
متن کاملMolecular Signature to Risk-Stratify Prostate Cancer of Intermediate Risk.
A new 30-gene signature has been described that separates prostate cancers of Gleason score ≤6 from those of Gleason score ≥8. It provides independent prognostic information for prostate cancers of intermediate risk (Gleason score of 7), which has the potential to stratify these patients into different risk groups. Clin Cancer Res; 23(1); 6-8. ©2016 AACRSee related article by Sinnott et al., p....
متن کاملFinding Molecular Signature of Prostate Cancer: An Algorithmic Approach
Abstract African American men in America are 65% more likely to develop prostate cancer and are two to three times more likely to die of the disease than Caucasian men [1]. While research indicates a strong hereditary link in prostate cancer, it has been difficult to pin down the exact genes involved in this disease. Many men develop prostate cancer later in life, and some men may die before pr...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Science Translational Medicine
سال: 2013
ISSN: 1946-6234,1946-6242
DOI: 10.1126/scitranslmed.3006408